Newsletter
Published: 6 Jan 2026, 22:42 IST

Alumis TYK2 psoriasis drug shows promise with Phase 3 results, doubling shares and competing with Takeda and Johnson & Johnson.

• Alumis reports positive Phase 3 results for TYK2 drug.
• Drug targets psoriasis, competing with Takeda and J&J.
• Shares more than doubled, indicating strong market interest.

Strategic Shift

Alumis has announced promising results from its Phase 3 clinical trial for its TYK2 inhibitor, envudeucitinib, targeting psoriasis. The trial results have led to a significant increase in the company’s stock value, with shares more than doubling. This development positions Alumis as a strong competitor in the psoriasis treatment market, alongside major players such as Takeda and Johnson & Johnson. The positive outcome of the trial suggests that envudeucitinib may offer a favorable alternative to existing oral treatments for psoriasis.

The trial involved a substantial number of participants, although the exact number remains undisclosed. The results indicate that envudeucitinib met its primary endpoints, demonstrating efficacy in reducing the severity of psoriasis symptoms. This success is crucial for Alumis as it seeks to establish a foothold in the competitive market for psoriasis treatments. Read more about the trial results here.

Market Context

The psoriasis treatment market is highly competitive, with several pharmaceutical companies vying for dominance. Alumis’ entry into this market with its TYK2 inhibitor is significant, as it offers a new oral treatment option for patients. Takeda and Johnson & Johnson are among the key competitors in this space, each developing their own oral therapies for psoriasis. The success of envudeucitinib in clinical trials positions Alumis to capture a share of this lucrative market.

Psoriasis affects millions of people worldwide, creating a substantial demand for effective treatments. Current standard treatments include biologics and topical therapies, but there is a growing interest in oral medications due to their convenience and potential efficacy. Alumis’ positive trial results suggest that envudeucitinib could become a preferred choice for patients seeking an oral treatment option.

Pipeline Expansion

Alumis’ success with envudeucitinib is part of a broader strategy to expand its pipeline of innovative therapies. The company is focused on developing treatments that address unmet medical needs, particularly in the field of autoimmune diseases. The positive Phase 3 results for envudeucitinib are expected to accelerate Alumis’ efforts to bring the drug to market.

Analysts are optimistic about the potential impact of envudeucitinib on Alumis’ financial performance. The doubling of the company’s share price following the announcement of the trial results reflects strong investor confidence in the drug’s commercial prospects. As Alumis prepares for potential regulatory submissions, it will be closely watched by industry stakeholders.

For more updates on Clinical Trials & R&D, visit our Clinical Trials & R&D section.